There are several options for defense.
Monk - Protection Prayers (negate 1 attack or reduce damage, curing conditions), Healing Prayers, Rebirth, removing hexes
Warrior - Tactic Stances (receive 75% blocking, immune to knockdowns)
Ranger - Wilderness Survival (stances, poison, healing), Beast Mastery (healing, extra health, faster attacks, a pet)
Necromancer - transfering conditions, explosive minions, healing, weakening enemy defenses
Ritualist - Communion Rituals (reduce damage, evades), Flesh of My Flesh, global healing
Elementalist - Wards, AoE around you
Mesmer - Stances, Domination Magic, Illusion Magic, best energy management
I have taken A/Mo (like many others) because I want to remove conditions and hexes (since assassins can't). I would also like to make sure that I can rez everyone else when they die (and I'm still alive). I've played this game long enough to know when to run and when to fight.
Hope this helps.
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